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Pineal gland; day and night

Human

(experiment details)
gene ENSG00000129673
gene name AANAT
gene biotype protein_coding
chrom chr17
mean 88.6
stddev 22.23
Official full name aralkylamine N-acetyltransferase
Summary The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
gene id ENSG00000129673
coordinates chr17:76453351-76470117

Open UCSC track hub for this gene (see help)